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Notwithstanding the well known association of diabetes and infection we have little definite knowledge of the mechanism by which these two conditions affect each other. Since the days of Claude Bernard, clinicians have viewed with alarm either the appearance of infection during the course of diabetes, or, perhaps with less apprehension, the occurrence of diabetes during or following an infection. In considering the coincidence of these disorders one might distinguish between the effect of each upon the other as different though essentially interdependent problems. Various degrees of importance have been accorded to infection in the etiology of diabetes but there is general agreement regarding the harmful effect of infection when occurring during the course of diabetes. The resistance of the body to infection is attributed in part to the antigen-amboceptor-complement reactions of the blood. We have no knowledge regarding the influence of diabetes on these reactions nor on the formation of amboceptor or complement. The former may be present in the blood, as in natural immunity, or it may be formed following the inoculation of bacteria into the body, as in acquired immunity. Complement appears to be always present and to react with either type of amboceptor. In this study, complement, natural amboceptor and acquired amboceptor, as factors in the antibacterial power of the blood, have been investigated in diabetic and non-diabetic persons to determine whether this part of the protective mechanism of the blood is affected by diabetes. The complement of the serum was measured in hemolytic and bacteriolytic systems. The bactericidal power of the whole blood was chosen as the best method of determining the native amboceptor (1, 2). The formation of agglutinins following inoculation with B. typhosus vaccine was taken as the index of formation of acquired amboceptor.

IMMUNITY IN DIABETES: INFLUENCE OF DIABETES ON THE DEVELOPMENT OF ANTIBACTERIAL PROPERTIES IN THE BLOOD