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The search for additional forms of treatment for peptic ulcer refractory to the usual medical and surgical treatment has led to the introduction of many innovations. Among these is the injection of nonspecific protein, first introduced by Holler in 1921 (3) and later advocated by Pribram (9) and other investigators in Germany. Martin (4), Shaine (11), Meyer and Kartoon (6), and Schiff and Norris (10) have adequately reviewed the literature on this subject and outlined the development of this method of treatment. Briefly, it has been found that in cases of peptic ulcer symptoms of ulcer disappear completely for a variable length of time following the parenteral injection of various protein substances. Reports are at variance as to the percentage of patients who obtain relief, the duration of symptomatic improvement, and the probable effects of the procedure on the healing of ulcer. Also, little is known about the effects of the injection of foreign protein on gastric secretion and motility in normal and diseased human subjects. This paper sums up the results of work which we have done in an attempt to answer all these questions and in addition to determine the effects of the procedure on the gastric motor and secretory functions of dogs.

THE EFFECT OF INJECTION OF NONSPECIFIC PROTEIN ON THE PAIN OF ULCER AND ON GASTRIC SECRETION: A CLINICAL AND EXPERIMENTAL STUDY