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The range of variation in serum calcium is relatively narrow in health and in most diseases. The accepted normal level is from 9 to 11 mgm. for each 100 cc. of serum or plasma. Lowered values for serum calcium have been found in tetany (parathyroid), rickets, nephritis, osteomalacia and sprue; elevated values are rare. High values have been found by Wells in terminal acidosis and by Coates and Raiment in gout, averaging 19 mgm. for each 100 cc. of serum; these data, however, have been questioned by Cameron. Horowitz has reported values as high as 16.8 mgm. for each 100 cc. of serum in cases of acute gout, and values as high as 16.2 mgm. in five of fourteen cases of arthritis deformans. Hench found that the serum calcium was normal in four cases of gout and in twenty-five cases of infectious arthritis. The calcium content of the whole blood in healthy subjects has been found by Kramer and Tisdall (16) to vary from 5.3 to 6.8 mgm. for each 100 cc. of blood. Calcium is absent, or present in small amounts, in the corpuscles of the blood. The calcium content of the whole blood and of the serum in cases of polycythemia vera has not been carefully studied, probably because of the relative rarity of the disease. Rabinowitch (18), employing McCallum's gravimetric method (quantitative determination of calcium as calcium oxide) found lowered serum calcium in two cases of polycythemia vera.

THE REDUCTION OF HYPERCALCEMIA IN CASES OF POLYCYTHEMIA VERA BY PHENYLHYDRAZINE 1