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A diminution in the surface tension of the blood serum has been found in many cases of hyperthyroidism as reported in a previous paper (1). Since it is well known that the unsaturated fatty acids are highly surface active, we have investigated the amount of these substances in relation to the plasma fats as a possible cause of the above observed phenomenon in patients with this disease. The blood fats in a short series of normal persons studied at the same time as a basis for comparison. Sixteen cases of hyperthyroidism and exophthalmic goitre have been studied. The blood was collected shortly after the patient was admitted to the ward and before the administration of iodine was commenced. Determinations were again made when the therapeutic effect of the iodine administered was considered to be at its maximum, and still later after surgical operation. Iodine was administered in the form of Lugol's solution, the usual dosage being 30 minims daily. In many cases the administration of Lugol's solution was continued for a short period after operation in dosage of 5 to 10 minims daily. The patients were given no food for at least sixteen hours before collection of the blood for study. The basal metabolic rate was determined when possible the same day that the blood was taken, and also at frequent intervals thereafter.

THE PLASMA FATS AND THE IODINE ABSORPTION CAPACITY OF THE FATTY ACIDS IN HYPERTHYROIDISM