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The compound heterozygous mutations in the β subunit of chaperonin containing TCP-1 (CCT), encoded by CCT2, lead to the Leber congenital amaurosis (LCA). In this study, a cct2 mutant line of zebrafish was established to investigate the role of CCT2 mutations in LCA in vertebrates.

investigative ophthalmology and visual science

Mutation in the Zebrafish <i>cct2</i> Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of <i>CCT2</i>-Related Leber Congenital Amaurosis

Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis