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Prolyl hydroxylases (PHDs) are oxygen sensors that stabilize hypoxia-inducible factors (HIFs) to induce proinflammatory, vasopermeability, and proapoptotic factors. These may be potential targets to reduce the complications of ischemic retinopathies.

investigative ophthalmology and visual science

Reduced Retinal Neovascularization, Vascular Permeability, and Apoptosis in Ischemic Retinopathy in the Absence of Prolyl Hydroxylase-1 Due to the Prevention of Hyperoxia-Induced Vascular Obliteration