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With age, large amounts of crystallins become associated with fiber cell membranes in the human lens nucleus, and it has been proposed that this binding of protein may lead to the obstruction of membrane pores and the onset of a barrier to diffusion. This study focused on membrane binding within the barrier region and the outermost lens cortex.

Large-Scale Binding of α-Crystallin to Cell Membranes of Aged Normal Human Lenses: A Phenomenon That Can Be Induced by Mild Thermal Stress