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To determine whether intraocular pressure (IOP) elevation alters OPA1 expression and triggers OPA1 release, as well as whether the uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist memantine blocks OPA1 release and subsequent apoptotic cell death in glaucomatous DBA/2J mouse retina.

Memantine Blocks Mitochondrial OPA1 and CytochromecRelease and Subsequent Apoptotic Cell Death in Glaucomatous Retina