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Elevated hydrostatic pressure induces retinal ganglion cell (RGC) apoptosis in culture. The authors investigated whether the transient receptor potential vanilloid 1 (TRPV1) channel, which contributes to pressure sensing and Ca(2+)-dependent cell death in other systems, also contributes to pressure-induced RGC death and whether this contribution involves Ca(2+).

TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2+with Exposure to Hydrostatic Pressure

TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca²⁺with Exposure to Hydrostatic Pressure