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Trachoma remains the leading preventable infectious cause of blindness in developing countries. Human leukocyte antigen (HLA) associations with ocular disease severity and persistent Chlamydia trachomatis infection of Tanzanians living in trachoma-endemic villages were examined to determine possible protective candidate allotypes for vaccine development.

Human Leukocyte Antigen (HLA)-B, DRB1, and DQB1 Allotypes Associated with Disease and Protection of Trachoma Endemic Villagers