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Calpain-mediated C-terminal cleavage of alpha A-crystallins occurs during aging and cataractogenesis. The objective of the present study was to explore the role of the ubiquitin-proteasome pathway (UPP) in degrading C-terminal truncated alpha A-crystallins.

Degradation of C-terminal Truncated αA-crystallins by the Ubiquitin–Proteasome Pathway