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The use of herbal drugs for primary care is nowadays central to the global health system. In developing countries, it meets both economic and socio-cultural requirements. However, this increase about the use of herbal medicines has led to various forms of abuses related to factors that are generally extrinsic to the drug, such as incorrect botanical identification, falsification, fungal or bacterial contamination, etc. The need for the standardization of herbal drugs is more than ever important for the viability of phytotherapy. This study focuses on saye, a mixture of three plants including the root of Cochlospermum planchonii; the whole plant of Phyllanthus amarus and the leaves of Cassia alata. This traditional polyherbal formulation that we intend to promote is used in Burkina Faso as a herbal tea to treat malaria. In this present study, the aim is to control the quality and standardization of the saye and its different components in order to produce an antimalarial phytomedicine. More precisely, we present here, the phytochemical composition and physico-chemical study of the mixture and the vegetable raw materials. In this study, we are particularly concerned with the study of organoleptic properties, moisture content, total ash content, successive extraction yields, fingerprinting by thin layer chromatography, phytochemical screening and total flavonoids content. To evaluate the content of flavonoids selected as chemical bioactive marker, we used a method of spectrophotometric assay. The phytochemical study established fingerprints, identified the main secondary metabolites and determined the total flavonoid content in a selective extract of the saye. The physico-chemical analysis provided satisfactory results on the main indices, such as moisture content, total ash, heavy metals, etc. These results indicate a good treatment of plant raw materials and will certainly be used for the standardization of the drug and its quality control for future clinical studies.

science journal of analytical chemistry

Standardisation Process of &amp;lt;i&amp;gt;Saye&amp;lt;/i&amp;gt;, a Traditional Polyherbal Formulation Remedy for Malaria: Physico-chemical Analysis and Phytochemical Investigation