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Background: Breast cancer is the most common cancer and an important cause of death in women. It has psychological and social repercussions in patients. Objective: We aimed to assess triple negative breast cancer characteristics, patterns and time of disease relapse. Patients and methods: We reviewed the clinical files and pathology reports of 100 patients who had primary triple-negative breast cancer between 2013 -2017 at the oncology center, Tishreen University Hospital in Lattakia, Syria. We collected the information about (age at diagnosis, histological subtype of tumor, histological grade, tumor size, tumor stage, lymph node status), which was taken at the time of diagnosis. We used SPSS in this research, and Chi-square test was used to compare variables. Results: We found that most of patients (85%) were 40 years of age and older when diagnosed with breast cancer. The most common histological subtype was invasive ductal carcinoma IDC (84%). Regarding the size of the primary tumor, the majority (72%) were T2. According to lymph node status at diagnosis, 41 patients (41%) were N0, (33%) of total were N1. We found grade 2 in 52%, followed by grade3 (41%). For the tumor clinical stage, it was according to AJCC 7th edition, stage II (63%) and stage III in (30%). We found that 32 patients had a recurrence (32%) while (68%) had no recurrence during the follow-up period. As for the development of recurrence, (40.6%) had visceral recurrence; the most pattern was hepatic (61.5%) then pulmonary (38.5%). Recurrence occurred in (22 of 32) patients during the first 2 years (68.7%). We found a significant association between lymph node status and recurrence in patients with TNBC (P=0.004) Conclusion: T and N were important predictive factors for relapse in patients with triple-negative breast cancer, which tends to recur often during the first two years of diagnosis with distant metastases as well as localized recurrence.

Pathological and Clinical Characteristics of Triple Negative Breast Cancer and Disease Relapse