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A robust method for voxel by voxel enhancement of Cone-beam CT (CBCT) images using a priori knowledge from the planning Computed Tomography (pCT) scan has been developed and used to evaluate the dosimetric accuracy of pCT based CBCT correction method for SBRT dose verification in lung metastasis. This is a retrospective study under which SBRT is carried out in 10 patients presented with lung metastasis. pCT images of patients were acquired and treatment planning was carried out on Varian Eclipse (V11) for 30 Gy in 5 fractions. Daily imaging using CBCT has been done for each patient with an On-Board Imaging system. CBCT is corrected using Matlab function considering CT as fixed and CBCT as moving, the images are registered. Planning target volume (PTV), lung, heart and spine were recontoured on uncorrected CBCT and corrected CBCT separately and the calculated plan on CT is recalculated on both the CBCTs. The dose distribution between the pCT and both the CBCT images were compared. A paired sample test was performed to test the variations. The distribution of pixel intensity of corrected CBCT is closer to the pCT than the uncorrected CBCT. The maximum percentage difference between the corrected CBCT and pCT is 1% in PTV evaluation, which is 3.5% between uncorrected CBCT and pCT. The method increases the accuracy of CBCT density values and enabling the use of CBCT images for dose calculation in radiotherapy.

A Method to Correct Cone Beam CT (CBCT) Images Using Planning CT for Derivation of Plan of the Day in STEREOTACTIC Body Radiotherapy (SBRT)