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Nasal-type NK/T-cell lymphoma (nasal-type NKTL) is one of the most lethal cancers for. Our study aimed to identify hub differentially expressed genes (DE- genes) and their upstream microRNAs between nasal-type NK/T-cell lymphoma (NKTL) tumor samples and normal nasal tissues through integrated bioinformatics. The 503 DE-genes and 106 DE-miRNAs were identified between NKTL and human normal nasal samples. GO and KEGG analysis were significantly enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, deubiquitination, enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, and stem cell division. And 11 differential expression hub genes and their upstream microRNAs were identified between nasal-type NKTL and normal nasal samples. In summary, after a series of analyses, we found that 11 hub DE-genes and their upstream DE-miRNAs (CDC27- miR-548c-3p, FREM2- miR-373*, ARHGAP29-miR-548c-3p, QSER1-miR-548c-3p, CD3EAP-miR-149*, SF3A1- miR-548c-3p, AQP4-miR-29b, ZFP36L2-miR-142-3p, SRP72-miR-16, TSC22D2-miR-16, TSC22D2-let-7f, DOCK5-miR-16) between nasal-type NKTL and normal nasal samples. They are highly likely to be serve as promising biomarkers in nasal-type NKTL.

cancer research journal

Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis