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AGO2, a protein-coding and miRNA regulating gene, has recently been identified as a phenomenal biomarker in cancer development research. Its role varies in different cancers, acting as either a tumor suppressor or an oncogene. However, no research has been conducted on the correlation between AGO2 and brain cancer yet. The aim of this study was to define the association of AGO2 amplification and brain cancer patient’s survival and to investigate the functional role of AGO2 in brain cancer cell migration. 20 brain cancer studies with a total of 6164 patient samples via cBioPortal were analyzed. After the patients were divided into two groups: AGO2 amplified group and AGO2 non-amplified group, the overall patients’ survival rate was analyzed by Kaplan-Meier. The positive correlation between the AGO2 amplified group and survival rates was discovered. To find out how AGO2 amplification increased patients’ survival rates, we performed an in vitro assay to silence AGO2 expression using two siRNAs targeting AGO2 in A172 brain cancer cell line. The wound-healing assay was performed to show that both siRNAs targeting AGO2 promoted cell migration of A172. Therefore, AGO2 may function as a tumor suppressor and enhances survival rates of brain cancer patients by inhibiting cancer cell migration. Further investigation of the mechanisms affecting AGO2 dysregulation will provide insights into the molecular differences underpinning brain cancer patient’s survival rate.

Effect of AGO2 Depletion on Cell Migration of A172 Brain Cancer Cell