The Effectiveness of Topical Mangosteen Pericarp Extract on the Collagen of Mice Skin Exposed to Ultraviolet B

Exposure to ultraviolet B (UVB) has an impact in the form of changes in the dermis collagen fibers and can result in decreasing the thickness and density of collagen. This study aims to assess the effectiveness of mangosteen pericarp extract to the thickness and density of collagen in mice skin after being exposed to UVB. This research was conducted in the animal laboratory and the anatomic pathology laboratory Hasanuddin University, Makassar. The study used pure animal experimental research design with control group. The samples were 24 mice that were divided into four groups: normal, UVB, ethanol and mangosteen groups. Mangosteen pericarp extract with a concentration of 50% was applied shortly after the mice were exposed to UVB. The thickness and density of collagen in normal group was significantly higher than UVB and ethanol groups. Mangosteen groups showed collagen density higher than UVB and ethanol groups. No significant differences between mangosteen and normal group. No significant differences between ethanol and UVB groups. Mangosteen pericarp extract with a concentration of 50% (2 mg / gBW mice) can increase the thickness and density of collagen in mice skin exposed to UVB.