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α1-Antitrypsin (A1AT) was identified as a plasma protease inhibitor; however, it is now recognized as a multifunctional protein that modulates immunity, inflammation, proteostasis, apoptosis, and cellular senescence. Like A1AT, protein phosphatase 2A (PP2A), a major serine-threonine phosphatase, regulates similar biologic processes and plays a key role in chronic obstructive pulmonary disease.

α1-Antitrypsin Activates Protein Phosphatase 2A to Counter Lung Inflammatory Responses

α₁-Antitrypsin Activates Protein Phosphatase 2A to Counter Lung Inflammatory Responses