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The immunologic events surrounding primary Mycobacterium tuberculosis infection and development of tuberculosis remain controversial. Young children who develop tuberculosis do so quickly after first exposure, thus permitting study of immune response to primary infection and disease. We hypothesized that M. tuberculosis-specific CD8(+) T cells are generated in response to high bacillary loads occurring during tuberculosis.

CD8+ T Cells Provide an Immunologic Signature of Tuberculosis in Young Children

CD8⁺ T Cells Provide an Immunologic Signature of Tuberculosis in Young Children