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Chronic obstructive pulmonary disease is a leading cause of death worldwide, but its pathogenesis is not well understood. Previous studies have shown that airway surface dehydration in beta-epithelial Na(+) channel (betaENaC)-overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors.

Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+ Channel–Overexpressing Mice

Development of Chronic Bronchitis and Emphysema in β-Epithelial Na⁺ Channel–Overexpressing Mice