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There is growing evidence that alveolar cell apoptosis plays an important role in emphysema pathogenesis, a chronic inflammatory lung disease characterized by alveolar destruction. The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antiprotease imbalance mediates cigarette smoke-induced emphysema.

A Novel Antiapoptotic Role for α1-Antitrypsin in the Prevention of Pulmonary Emphysema

A Novel Antiapoptotic Role for α₁-Antitrypsin in the Prevention of Pulmonary Emphysema