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Attempting to compare scientific theories requires a philosophical model of meaning. Yet different scientific theories have at times—particularly in early chemistry—pre-supposed disparate theories of meaning. When two theories of meaning are incommensurable, we must say that the scientific theories that rely upon them are meta-incommensurable. Meta-incommensurability is a more profound sceptical threat to science since, unlike first-order incommensurability, it implies complete incomparability.

Meta-Incommensurability between Theories of Meaning: Chemical Evidence