Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice | Zendy

Katharina EikermannHaerter | Zendy; Jeong Hyun Lee | Zendy; Nilufer Yalcin | Zendy; Esther S. Yu | Zendy; Ali Daneshmand | Zendy; Ying Wei | Zendy; Yi Zheng | Zendy; Anil Can | Zendy; Buse Sengul | Zendy; Michel D. Ferrari | Zendy; Arn M. J. M. van den Maagdenberg | Zendy; Cenk Ayata | Zendy

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Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice

Author(s) -

Katharina EikermannHaerter,

Jeong Hyun Lee,

Nilufer Yalcin,

Esther S. Yu,

Ali Daneshmand,

Ying Wei,

Yi Zheng,

Anil Can,

Buse Sengul,

Michel D. Ferrari,

Arn M. J. M. van den Maagdenberg,

Cenk Ayata

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.006982

Subject(s) - medicine , migraine , topiramate , cortical spreading depression , stroke (engine) , anesthesia , migraine with aura , ischemia , lamotrigine , familial hemiplegic migraine , cardiology , aura , epilepsy , psychiatry , mechanical engineering , engineering

Migraine with aura is an established stroke risk factor, and excitatory mechanisms such as spreading depression (SD) are implicated in the pathogenesis of both migraine and stroke. Spontaneous SD waves originate within the peri-infarct tissue and exacerbate the metabolic mismatch during focal cerebral ischemia. Genetically enhanced SD susceptibility facilitates anoxic depolarizations and peri-infarct SDs and accelerates infarct growth, suggesting that susceptibility to SD is a critical determinant of vulnerability to ischemic injury. Because chronic treatment with migraine prophylactic drugs suppresses SD susceptibility, we tested whether migraine prophylaxis can also suppress ischemic depolarizations and improve stroke outcome.

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