Potential Role of PUMA in Delayed Death of Hippocampal CA1 Neurons After Transient Global Cerebral Ischemia | Zendy

Kuniyasu Niizuma | Zendy; Hidenori Endo | Zendy; Chikako Nito | Zendy; D. Jeannie Myer | Zendy; Pak H. Chan | Zendy

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Potential Role of PUMA in Delayed Death of Hippocampal CA1 Neurons After Transient Global Cerebral Ischemia

Author(s) -

Kuniyasu Niizuma,

Hidenori Endo,

Chikako Nito,

D. Jeannie Myer,

Pak H. Chan

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.524447

Subject(s) - puma , hippocampal formation , ischemia , downregulation and upregulation , medicine , apoptosis , hippocampus , programmed cell death , neuroscience , brain ischemia , biology , endocrinology , biochemistry , gene

p53-upregulated modulator of apoptosis (PUMA), a BH3-only member of the Bcl-2 protein family, is required for p53-dependent and -independent forms of apoptosis. PUMA localizes to mitochondria and interacts with antiapoptotic Bcl-2 and Bcl-X(L) or proapoptotic Bax in response to death stimuli. Although studies have shown that PUMA is associated with pathomechanisms of cerebral ischemia, clearly defined roles for PUMA in ischemic neuronal death remain unclear. The purpose of this study was to determine potential roles for PUMA in cerebral ischemia.

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