Enhanced Expression of Lp-PLA 2 and Lysophosphatidylcholine in Symptomatic Carotid Atherosclerotic Plaques | Zendy

Dallit Mannheim | Zendy; Sandra M. Herrmann | Zendy; Daniele Versari | Zendy; Mario Gössl | Zendy; Fredric B. Meyer | Zendy; Joseph P. McConnell | Zendy; Lilach O. Lerman | Zendy; Amir Lerman | Zendy

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Enhanced Expression of Lp-PLA ₂ and Lysophosphatidylcholine in Symptomatic Carotid Atherosclerotic Plaques

Author(s) -

Dallit Mannheim,

Sandra M. Herrmann,

Daniele Versari,

Mario Gössl,

Fredric B. Meyer,

Joseph P. McConnell,

Lilach O. Lerman,

Amir Lerman

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.503193

Subject(s) - medicine , asymptomatic , pathology , cd68 , sirius red , inflammation , fibrosis , staining , immunostaining , gastroenterology , immunohistochemistry

Circulating lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has emerged as a novel biomarker for cardiovascular diseases. However, the correlation between the plaque expression of Lp-PLA(2) and plaque oxidative stress, inflammation, and stability as well as the clinical presentation remains poorly defined, especially for cerebrovascular disease. Therefore, this study was performed to test the hypothesis that Lp-PLA(2) expression is higher in symptomatic than in asymptomatic carotid plaques of patients undergoing carotid endarterectomy.

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