Increased Severity of Hemorrhage in Transgenic Mice Expressing Cerebral Protease Nexin-2/Amyloid β-Protein Precursor | Zendy

Feng Xu | Zendy; Mary Lou Previti | Zendy; William E. Van Nostrand | Zendy

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Increased Severity of Hemorrhage in Transgenic Mice Expressing Cerebral Protease Nexin-2/Amyloid β-Protein Precursor

Author(s) -

Feng Xu,

Mary Lou Previti,

William E. Van Nostrand

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.480103

Subject(s) - medicine , thrombosis , genetically modified mouse , in vivo , pathology , endocrinology , transgene , biochemistry , biology , microbiology and biotechnology , gene

Secreted isoforms of amyloid beta-protein precursor (AbetaPP) that contain the Kunitz proteinase inhibitor domain, also known as protease nexin-2 (PN2), are enriched in brain. Although little is known of its physiological function, the potent inhibition of certain prothrombotic proteinases by PN2/AbetaPP suggests that it may function to regulate cerebral thrombosis during vascular injury events.

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