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P106 Objectives: Impaired platelet function has been  associated with increased propensity for ICH. Our objective is to  demonstrate that patients with larger ICH volume have abnormal platelet  function.Methods: This is a prospective cohort study.  Platelet function was measured by a standard set of tests within one  week of ICH. CT scans were performed within 24 hours of the event and  ICH volume determined by the ABC/2 method.Results: 12  patients were enrolled (5/12 female, 7/12 male). The mean age was 64  years (range 40–85). Four patients were on ASA. Platelet count ranged  from 76 to 315 KU/mm3 . Patients were divided into two  subgroups based on ICH size: ≤30cc and &gt;30cc. The two CT subgroups  were similar with respect to age, sex, race, history of hypertension  and alcohol abuse. We report in Table 1 the distribution of specific  platelet abnormalities among the two ICH groups.Conclusions: Large spontaneous ICH (&gt;30cc) is associated  with evidence of platelet hypoactivity which appear to extend beyong  ASA  effect.

The effect of platelet function abnormalities on the volume of spontaneous intracerebral hemorrhage(ICH)