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P94 Background and Purpose: Diffusion-weighted imaging  (DWI) allows measurement of ischemic lesions in a real-time manner and  is used increasingly for evaluation of stroke therapy. This study was  to determine if lesion growth is different when the initial lesion  volumes on DWI are different after permanent middle cerebral artery  occlusion (MCAO) in rats.Methods: Twelve Sprague-Dawley  male rats were subjected to permanent MCAO with the intraluminal suture  method. DWI was performed at 30, 60, 90, 150, 210, and 270 minutes  after occlusion. The ischemic lesion areas were determined by visually  tracing the hyperintense border on DWI, and the lesion volumes were  calculated by multiplying the areas by the slice thickness. Based on  the initial lesion volume at 30 minutes, the rats were evenly assigned  to two groups: group A with smaller initial volume (&lt;130  mm3 , n=6) and group B with larger initial volume (≥130  mm3 , n=6).Results: The initial lesion volumes  at 30 minutes were significantly different between two groups (106±14  mm3 vs 189±38 mm3 , p&lt;0.001), and the lesion  volumes were also different thereafter (189±35 mm3 vs  270±76 mm3 at 270 minutes, p=0.04). The absolute increased  volumes at 270 minutes, however, had no difference between two groups  (84±32 mm3 in group A and 82±44 mm3 in group  B, p=0.93). The percent increase of the lesion volume in group A was  bigger than that in group B (80±30% vs 42±17% at 270 minutes,  p=0.02).Conclusions: The growth rate of the ischemic lesion  is larger if the initial lesion volume is smaller, but the absolute  increase of the lesion volume is similar regardless of the difference  of the initial lesion volume. These findings are of importance in  evaluating the efficacy of stroke therapy when the initial lesion  volumes are different.

Growth pattern of ischemic lesions with different initial volume in a permanent middle cerebral artery occlusion model