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P79 Bone morphogenetic protein-7 (BMP-7) (=osteogenic protein-1,  OP-1) has been shown to enhance dendritic growth and improve functional  recovery after experimental stroke. In this study, we examined the  effect of BMP-7 on local cerebral blood flow (LCBF) and local cerebral  glucose utilization (LCMRglu) following transient middle cerebral  artery occlusion. Sprague Dawley rats (n=29) were anesthetized with  halothane/nitrous oxide and received 2-h middle cerebral artery  occlusion (MCAo) by poly-L-lysine coated intraluminal suture (1).  Rectal and cranial (left temporalis muscle) temperatures were regulated  at 37–37.5o C. BMP-7 or vehicle (volume, 25μl) was  administered intracisternally in blinded fashion at 24h after MCAo.  Neurological status was evaluated during occlusion (60 min) and daily  for 2 days after MCAo; a grading scale of 0–12 was employed (1).  LCMRglu was measured autoradiographically with14 C-2  deoxyglucose (2-DG) and LCBF with14 C-iodoantipyrine  48 h after MCAo. Four animals groups were studied: LCMRglu series  (BMP-7, n=7; vehicle, n=8); LCBF series (BMP-7, n=6; vehicle, n=8).  Average three-dimensional image data sets were constructed for each  group and were compared by pixel-based statistical methods (2). Rectal  and cranial temperatures, MABP, plasma glucose and blood gases were  similar among groups. BMP-7 significantly improved the neurological  score compared to vehicle at 48 after MCAo (7.3 ± 0.4 vs.  9.0 ± 0.2, respectively; p&lt;0.0003). Compared to vehicle-rats,  BMP-7 significantly increased LCMRglu in ipsilateral basal ganglia,  improved LCBF in ipsilateral subthalamus, and decreased LCBF and  LCMRglu in contralateral cortical regions. The improved glucose  metabolism in ipsilateral basal ganglia of BMP-7 rats is compatible  with its salutary influence on neurological recovery. Supported by  Creative BioMolecules, Inc., Hopkinton, MA, and by NIH Grant NS 05820.  (1)Belayev L, Alonso OF, Busto R, Zhao W, Ginsberg MD: Stroke  27:1616–1623,1996. (2)Zhao W, Belayev L, Ginsberg MD: J Cereb  Blood Flow Metab 17:1281–1290,1997.

stroke

The Effect of the Dendritic Growth Factor BMP-7 on Local Cerebral Glucose Utilization and Blood Flow in Reversible Middle Cerebral Artery Occlusion in Rats