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111 Objective: To determine the association  between carotid artery intimal-medial thickness (IMT) and functional  promoter variants of stromelysin-1 (MMP3 : -16125A&gt;6A),  interleukin-6 (IL6 : -174G&gt;C) and hepatic lipase  (HL : -480C&gt;T) genes.Background: Carotid artery  intimal-medial thickness (IMT) correlates well with pathologically  defined atherosclerosis, a complex multifactorial disorder with both  hereditary and environmental causes. IMT is also a risk factor for  stroke, myocardial infarction and death.Methods: High-resolution B-mode imaging and mean intimal-medial thickness (IMT)  measurements in common carotid arteries were obtained in 87 subjects  (mean age 70±12 years; 55% women; race-ethnicity: 60% Hispanic, 35%  black, 13% white) using a standardized carotid artery IMT protocol.  Genotyping was assessed using PCR amplification and restriction  digestion with enzymes specific to the alleles.Results: For  all polymorphisms genotype distribution was as expected from  Hardy-Weinberg proportions. The frequencies of the rare alleles at each  locus in the sample were:MMP3 5A 0.32 (95% CI,  0.25–0.39),IL6 -174C 0.19 (95% CI, 0.13–0.25) andHL -480T 0.42 (95% CI, 0.35–0.50). ForMMP3 andIL6, but notHL, these frequencies were  significantly lower than reported in Caucasian subjects. The overall  mean common carotid artery IMT was 0.86±0.20 mm. Subjects with the  genotypesMMP3 6A6A orHL CC had 8% greater mean  common carotid artery IMT than the other genotypes combined  (MMP3 6A6A: 0.93 mm vs. 0.86 mm, absolute IMT difference  =0.07 mm;HL CC: 0.93 mm vs. 0.86 mm, absolute IMT  difference = 0.07 mm). Subjects withIL6 GG had 2%  higher common carotid artery IMT compared to others combined  (IL6 GG: 0.89 mm vs. 0.87 mm, absolute IMT  difference).Conclusion: We observed higher  common carotid artery intimal-medial thickness in subjects homozygous  for specific candidate genes related to matrix deposition, lipid  metabolism and inflammation. Further studies with increased power are  needed to confirm these genotype-phenotipe associations.

stroke

The Association of Carotid Artery Intimal-Medial Thickness and Allelic Variants of Stromelysin-1, Interleukin-6 and Hepatic Lipase Genes: A Pilot Study from the Northern Manhattan Stroke Study