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37 OBJECTIVE: To reveal the intensity of the surface  expression of the adhesion molecules (CD11b/CD18) on monocytes and  neutrophils in the peripheral blood of patients with an acute brain  ischemia compared to healthy individuals who served as controls.BACKGROUND: The Leukocyte Integrin CD11b/CD18 is an  important receptor that is involved in the modulation of leukocyte to  endothelial interactions and is expressed in increased amounts during  cell activation. It has been previously suggested that activated white  blood cells, mainly polymorphonuclear leukocytes and monocytes,  participate in the development of ischemic vascular disorders by virtue  of their capability to obstruct the microvasculature and enhance tissue  damage.DESIGN/METHODS: Cellular surface expression of the  adhesion molecules CD11b/CD18 on the neutrophils and monocytes in the  peripheral blood was measured by a direct immunotechnique of flow  cytometry in two groups: patients who had transient ischemic attacks  (TIA) or ischemic stroke (confirmed by CT scans, within 24 hours from  onset of symptoms), and healthy individuals who served as controls.  Analysis was done by ANOVA test.RESULT: Seventy-one  patients and 150 controls were included in the study. The respective  mean fluorescence intensity for CD11b/CD18 being 161±76, 155±87 for  polymorphonuclear leukocytes and 231±99, 203±79 for monocytes. No  statistically significant difference was noted between the groups.CONCLUSIONS: The results of the present study show that  patients with acute cerebral ischemic event do not present increased  amount of the CD11b/CD18 antigen on the surface of the peripheral blood  polymorphonuclear or monocytes compared to control. Our data do not  support the hypothesis that the white blood cells participate in the  development of acute cerebral ischemia by the mechanism of activation  of the adhesion molecule CD11b/CD18.

stroke

Lack of an Increased Expression of the CD11b/CD18 Antigen on the Surface of Peripheral Blood Circulating Pool of Leukocytes in Patients with an Acute Neurological Ischemic Event