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Background Limited information exists regarding procedural success and clinical outcomes in patients with previous coronary artery bypass grafting (CABG) undergoing percutaneous coronary intervention (PCI ). We sought to compare outcomes in patients undergoingPCI with or withoutCABG .Methods and Results This was an observational cohort study of 123 780 consecutivePCI procedures from the Pan‐London (UK )PCI registry from 2005 to 2015. The primary end point was all‐cause mortality at a median follow‐up of 3.0 years (interquartile range, 1.2–4.6 years). A total of 12 641(10.2%) patients had a history of previousCABG , of whom 29.3% (n=3703) underwentPCI to native vessels and 70.7% (n=8938) to bypass grafts. There were significant differences in the demographic, clinical, and procedural characteristics of these groups. The risk of mortality during follow‐up was significantly higher in patients with priorCABG (23.2%;P =0.0005) compared with patients with no priorCABG (12.1%) and was seen for patients who underwent either native vessel (20.1%) or bypass graftPCI (24.2%;P &lt;0.0001). However, after adjustment for baseline characteristics, there was no significant difference in outcomes seen between the groups whenPCI was performed in native vessels in patients with previousCABG (hazard ratio [HR],1.02; 95%CI, 0.77–1.34;P =0.89), but a significantly higher mortality was seen among patients withPCI to bypass grafts (HR,1.33; 95%CI, 1.03–1.71;P =0.026). This was seen after multivariate adjustment and propensity matching.Conclusions Patients with priorCABG were older with greater comorbidities and more complex procedural characteristics, but after adjustment for these differences, the clinical outcomes were similar to the patients undergoingPCI without priorCABG . In these patients, native‐vesselPCI was associated with better outcomes compared with the treatment of vein grafts.

journal of the american heart association. cardiovascular and cerebrovascular disease

Prior Coronary Artery Bypass Graft Surgery and Outcome After Percutaneous Coronary Intervention: An Observational Study From the Pan‐London Percutaneous Coronary Intervention Registry