English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background It is currently unknown if antihypertensive drugs can be monitored in oral fluid (OF ) using liquid chromatography coupled to high‐resolution mass spectrometry.Methods and Results We assessed adherence using liquid chromatography coupled to high‐resolution mass spectrometry inOF , plasma, and urine of 56 consecutive patients with hypertension referred to a tertiary hypertension unit. Of these patients, 59% were completely adherent (all drugs detectable in urine), whereas 29% and 13% were partially adherent (1 drug not detectable in urine) or nonadherent (&gt;1 drug not detectable in urine), respectively. Adherent patients were on fewer antihypertensive drugs (P =0.001), had fewer daily drug doses (P =0.012), and had lower 24‐hour ambulatory systolic (P =0.012) and diastolic (P =0.009) blood pressures than nonadherent or partially adherent patients. Most drugs were detected in urine compared with plasma andOF (181 versus 119 versus 88;P =0.001). Compared with urine and plasma, detection rates of angiotensin‐converting enzyme inhibitors, angiotensinII receptor blockers, and diuretics were lower inOF . There was no difference in the frequency of detecting β blockers (P =1.0) and calcium channel blockers (P =0.063) when comparingOF with urine. There was no difference in the number of calcium channel blockers (P =0.727), β blockers (P =1.000), thiazide diuretics (P =0.125), and α‐2 agonists (P =0.125) identified betweenOF and plasma.Conclusions This study shows the feasibility of drug adherence testing for several antihypertensive drugs, especially those without acidic components, inOF , with a similar recovery compared with plasma. Therefore, drug adherence testing inOF should be further explored as a noninvasive approach, which can easily be performed in an “out‐of‐office” setting.

Adherence to Antihypertensive Drugs Assessed by Hyphenated High‐Resolution Mass Spectrometry Analysis of Oral Fluids