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The present study used a novel mouse model with proximal tubule-specific knockout of AT1a receptors in the kidney, PT-Agtr1a −/− , to test the hypothesis that intratubular Ang II (angiotensin II) and AT1a receptors in the proximal tubules are required for maintaining normal blood pressure and the development of Ang II–induced hypertension. Twenty-six groups (n=6–15 per group) of adult male wild-type, globalAgtr1a −/− , and PT-Agtr1a −/− mice were infused with Ang II (1.5 mg/kg per day, IP), or overexpressed an intracellular Ang II fusion protein in the proximal tubules for 2 weeks. Basal telemetry blood pressure were ≈15±3 mm Hg lower in PT-Agtr1a −/− than wild-type mice and ≈13±3 mm Hg higher thanAgtr1a −/− mice (P &lt;0.01). Basal glomerular filtration was ≈23.9% higher (P &lt;0.01), whereas fractional proximal tubule Na+ reabsorption was lower in PT-Agtr1a −/− mice (P &lt;0.01). Deletion of AT1a receptors in the proximal tubules augmented the pressure-natriuresis response (P &lt;0.01) and natriuretic responses to salt loading or Ang III infusion (P &lt;0.01). Ang II induced hypertension in wild-type, PT-Agtr1a −/− and PT-Nhe3 −/− mice, but the pressor response was ≈16±2 mm Hg lower in PT-Agtr1a −/− and PT-Nhe3 −/− mice (P &lt;0.01). Deletion of AT1a receptors or NHE3 (Na+ /H+ exchanger 3) in the proximal tubules attenuated ≈50% of Ang II–induced hypertension in wild-type mice (P &lt;0.01), but blocked intracellular Ang II fusion protein-induced hypertension in PT-Agtr1a −/− mice (P &lt;0.01). Taken together, the results of the present study provide new insights into the critical role of intratubular Ang II/AT1 (AT1a )/NHE3 pathways in the proximal tubules in normal blood pressure control and the development of Ang II–induced hypertension.

hypertension

Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II–Induced Hypertension in PT- <i>Agtr1a</i> <sup>−/−</sup> Mice

Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II–Induced Hypertension in PT- Agtr1a −/− Mice

Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II–Induced Hypertension in PT- Agtr1a ^−/− Mice