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See related article, pp 984–990After the publication of the initial experience in patients with hypertension resistant to conventional drug treatment in 2009,1 catheter-based renal denervation has attracted substantial interest not only from the hypertension community, but also from interventionalists and affected patients alike. Five years onward and not to everyone’s delight, renal denervation is now available in many countries throughout the world as an alternative therapeutic option for patients with treatment-resistant hypertension and additional criteria as defined in the Symplicity HTN-11 and HTN-2 studies.2Although the safety of radiofrequency ablation–based renal denervation procedures seems favorable with only a small number of reports of renovascular or renal compromise thus far, the rate of blood pressure response to renal denervation, typically defined as a reduction in office systolic blood pressure of ≥10 mm Hg,1,2 is more variable, with response rates reported in the range between ≈60% and 90%.3,4 An inherent question that arose was whether or not reliable predictors of the blood pressure response to renal denervation could be identified. Such predictors, if available, would not only assist in selecting the most appropriate patients for this interventional approach, but also help to avoid exposing nonsuitable patients to unnecessary risk and optimize the use of health-related funding resources.Indeed, in the majority of renal denervation studies published thus far, analyses were performed to address the issue of …

Biomarkers for the Prediction of Blood Pressure Response to Renal Denervation