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The interesting article by Turner et al1 concerns the pharmacogenomics of the angiotensin receptor blocker Candesartan and the validation of the associated single-nucleotide polymorphisms by their opposite direction associations with blood pressure response to hydrochlorothiazide.We are also performing a pharmacogenomic study of the angiotensin receptor blocker Losartan2 and hydrochlorothiazide in a slightly larger sample of white-only, essential hypertensives, carefully recruited …

Genomic Association Analysis Identifies Multiple Loci Influencing Antihypertensive Response to an Angiotensin II Receptor Blocker