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To the Editor:Peterzan et al1 provide a meta-analysis that examines the dose-response relationships on blood pressure for thiazide-like diuretics and find that chlorthalidone is ≈3 times more potent than hydrochlorothiazide (HCTZ) in reducing office systolic blood pressure. Their primary conclusion is that, “These differences in potency allied to the differences in pharmacokinetics are likely to account to a …

Potency of Office Blood Pressure From Hydrochlorothiazide and Chlorthalidone Fails to Explain Cardiovascular Events