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To the Editor:Salvi et al1 reported that the single nucleotide polymorphism (SNP) rs3918226 in the promoter of the endothelial NO synthase (eNOS) gene was associated with hypertension. Although no functional studies show how this SNP affects eNOS, the authors identified a potential binding site for ETS transcription factors directly next to rs3918226, thus suggesting a potential modulation of eNOS expression.1NO is mainly produced by eNOS in endothelial cells and is oxidized to nitrite, a useful index of endogenous NO formation that may show how genetic variations affect eNOS activity.2 We showed that eNOS polymorphisms modify …

Endothelial Nitric Oxide Synthase Polymorphism rs3918226 Associated With Hypertension Does Not Affect Plasma Nitrite Levels in Healthy Subjects