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To the Editor:Wray et al1 reported that acute consumption of antioxidants by healthy subjects had diametrically different effects: flow-mediated dilation increased in elderly people but decreased in young people. The opposite effects are difficult to interpret and reconcile with the measured biomarkers of oxidative stress and NO synthesis/bioavailability. Although not representative, an example for the strong limitation of acute changes is the enhancing effect of certain diuretics on the renal excretion of …

Antioxidants and Endothelial Dysfunction in Young and Elderly People: Is Flow-Mediated Dilation Useful to Assess Acute Effects?