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To the Editor:Since its discovery, NO has been recognized as a protective molecule for vascular function via its vasodilatory, antithrombotic, and antiapoptotic effects. The role of NO synthase (NOS) in the physiological control of vascular tone was clarified by experiments with the systemic administration of the pharmacological competitor NOS inhibitor, NG -nitro-l-arginine, which increases blood pressure in experimental animals. The spontaneous development of hypertension in mice with the endothelial isoform of NOS deleted demonstrated that endothelial cell–derived NO promotes vasodilation and opposes the development of hypertension.On the other hand, Smith et al1 demonstrated an upregulation of inducible NOS (iNOS) in microvessels of hypertensive subjects and an impressive restoration of …

Inducible Nitric Oxide Synthase Inhibition as a Target for the Treatment of Vascular Dysfunction in Hypertension