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To the Editor:Oxidative stress has been implicated in the pathogenesis of renal and cardiovascular diseases; however, there is still much to be learned. It is against this background that we read with great interest the article titled, “Superoxide Dismutase 1 Limits Renal Microvascular Remodeling and Attenuates Arteriole and Blood Pressure Responses to Angiotensin II via Modulation of Nitric Oxide Bioavailability,” by Carlstrom et al.1 The goal of this article was to determine the functional role of superoxide dismutase 1 (SOD1) in regulating renal microvascular function and blood pressure responses to angiotensin (Ang) II. The authors found that SOD1 …

Sex of the Animal Impacts Responses to Angiotensin II, Oxidative Stress Levels, and Nitric Oxide Bioavailability