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To the Editor:Mercure et al1 reported the targeted expression of mouse prorenin to the liver of mice. Liver expression of mouse prorenin was under the control of the transthyretin gene promoter, and plasma prorenin levels of these TTRmProren transgenic mice were increased by 13- to 28-fold. TTRmProren mice with 28-fold elevation of prorenin levels had hypertension and cardiac hypertrophy, but there was no increase in cardiac fibrosis or glomerular sclerosis in these mice. This study is an important …

Method of Blood Collection May Explain the Suppression of Plasma Renin Concentration in Prorenin Transgenic Mice