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Angiotensin II activates 2 distinct G protein-coupled receptors, the AT(1) and AT(2) receptors. Most of the known cardiovascular effects of angiotensin II are mediated by the AT(1) receptor subtype. The aim of the present study was to test whether deletion of the AT(2) receptor gene in mice (AT(2)-KO mice) leads to long-term functional or structural alterations in the cardiovascular system.

Vascular Hypertrophy and Increased P70S6 Kinase in Mice Lacking the Angiotensin II AT 2 Receptor

Vascular Hypertrophy and Increased P70S6 Kinase in Mice Lacking the Angiotensin II AT ₂ Receptor