Open AccessUpregulation of CD40 and CD40 Ligand (CD154) in Patients With Moderate Hypercholesterolemia
Author(s) -
Christoph D. Garlichs,
Stefan John,
Alexander Schmeißer,
Saeed Eskafi,
Christian Stumpf,
M. Karl,
Margarete GoppeltStruebe,
Roland E. Schmieder,
W. G. Daniel
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc4501.099312
Subject(s) - cd154 , medicine , cd40 , statin , platelet , monocyte , atorvastatin , endocrinology , inflammation , familial hypercholesterolemia , platelet activation , downregulation and upregulation , lipoprotein , cholesterol , in vitro , chemistry , biochemistry , cytotoxic t cell , gene
Hypercholesterolemia, a risk factor for cardiovascular disease, is associated with inflammation and hypercoagulability. Both can be mediated by the CD40 system. This study investigated whether the CD40 system is upregulated in patients with moderate hypercholesterolemia and whether it is influenced by therapy with a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
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