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We recently obtained evidence demonstrating that cultured bovine endothelial cells contain cytosolic proteins that form complexes with the 3'-untranslated region of endothelial nitric oxide synthase (eNOS) mRNA and are associated with its destabilization. The aim of this study was to determine the presence of such proteins and eNOS expression in hypercholesterolemic rabbits as an in vivo model of endothelial dysfunction.

Regulation of Endothelial Nitric Oxide Synthase Expression in the Vascular Wall and in Mononuclear Cells From Hypercholesterolemic Rabbits