Open AccessSelective Upregulation of Endothelin B Receptor Gene Expression in Severe Pulmonary Hypertension
Author(s) -
Michael Bauer,
Heinrike Wilkens,
Frank Langer,
Sven Schneider,
Henning Lausberg,
HansJoachim Schäfers
Publication year - 2002
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc0902.105719
Subject(s) - medicine , downregulation and upregulation , endothelin receptor , endothelin 1 , pulmonary hypertension , endocrinology , receptor , gene expression , pulmonary artery , percentile , vascular resistance , cardiology , gene , biology , hemodynamics , biochemistry , statistics , mathematics
The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent vasoactive and mitogenic peptide. Increased plasma ET-1 levels are observed in pulmonary arterial hypertension (PHT) and may contribute to the regulation of pulmonary vascular resistance, as well as to proliferative changes in the pulmonary vascular bed.
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