Open AccessProtection of Human Endothelial Cells From Oxidative Stress
Author(s) -
Giovanni Cuda,
Roberto Paternò,
Roberto Ceravolo,
Mafalda Candigliota,
Nicola Perrotti,
Francesco Perticone,
Maria Concetta Faniello,
Filippo Schepis,
Antonio Ruocco,
Evelina Mele,
Silvana Cassano,
Maurizio Bifulco,
Mariarosaria Santillo,
Enrico V. Avvedimento
Publication year - 2002
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc0802.104324
Subject(s) - medicine , oxidative stress , microbiology and biotechnology , endothelium , oxidative phosphorylation , endothelial stem cell , in vitro , biochemistry , biology , chemistry
Reactive oxygen species play a critical role in inducing apoptosis. The small GTPase p21 Ras and the ERK1/2 MAPK have been proposed as key regulators of the signaling cascade triggered by oxidative stress (H2O2). Harvey-Ras (Ha-Ras) and Kirsten-Ras (Ki-Ras) isoforms are so far functionally indistinguishable, because they activate the same downstream effectors, including ERK1/2. Moreover, ERK1/2 signaling has been involved in both protection and induction of apoptosis.
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