Open AccessInflammatory Response After Open Heart Surgery
Author(s) -
Brit Dybdahl,
Alexander Wahba,
Egil Lien,
Trude Helen Flo,
Anders Waage,
Nilofer Qureshi,
Olav F Münter Sellevold,
Terje Espevik,
Anders Sundan
Publication year - 2002
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc0602.103617
Subject(s) - cd14 , medicine , monocyte , tumor necrosis factor alpha , hsp70 , cytokine , receptor , interleukin , heat shock protein , immunology , macrophage , in vitro , biology , biochemistry , gene
Coronary artery bypass grafting with the use of cardiopulmonary bypass is known to mediate an inflammatory response. The stress-inducible heat-shock protein (HSP) 70 has been detected in myocardial cells after CABG, and toll-like receptors (TLRs) are suggested as putative signaling receptors for the HSPs, mediating synthesis of inflammatory cytokines. The main aims of our study were to explore the release of HSP70 and the regulation of monocyte TLR-2 and TLR-4 expression after CABG.
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