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Na(V)1.5 is a mechanosensitive voltage-gated sodium-selective ion channel responsible for the depolarizing current and maintenance of the action potential plateau in the heart. Ranolazine is a Na(V)1.5 antagonist with antianginal and antiarrhythmic properties.

Ranolazine Decreases Mechanosensitivity of the Voltage-Gated Sodium Ion Channel Na V 1.5

Ranolazine Decreases Mechanosensitivity of the Voltage-Gated Sodium Ion Channel Na _V 1.5