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inhibition of L-type Ca(2+) current contributes to negative inotropy of β(3) adrenergic receptor (β(3) AR) activation, but effects on other determinants of excitation-contraction coupling are not known. Of these, the Na(+)-K(+) pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na(+) levels and upregulation of the β(3) AR in heart failure.

β 3 Adrenergic Stimulation of the Cardiac Na + -K + Pump by Reversal of an Inhibitory Oxidative Modification

β ₃ Adrenergic Stimulation of the Cardiac Na ⁺ -K ⁺ Pump by Reversal of an Inhibitory Oxidative Modification